Some of the most recent publications:

2012

Saatchi K, Gelder N, Gershkovich P, Sivak O, Wasan KM, Kainthan RK, Brooks DE, Häfeli UO. Long-circulating non-toxic blood pool imaging agent based on hyperbranched polyglycerols: Int J Pharm. 2012 Jan 17;422(1-2):418-27.

Gershkovich P, Sivak O, Contreras-Whitney S, Darlington JW, Wasan KM. Assessment of cholesterol absorption inhibitors nanostructured aluminosilicate and cholestyramine using in vitro lipolysis model: J Pharm Sci. 2012 Jan;101(1):291-300.

2011

Leon CG, Lee J, Bartlett K, Gershkovich P, Wasan EK, Zhao J, Clement JG, Wasan K. In vitro cytotoxicity of two novel oral formulations of Amphotericin B (iCo-009 and iCo-010) against Candida albicans, human monocytic and kidney cell lines: Lipids Health Dis. 2011 Aug 20;10(1):144. [Epub ahead of print]

Sivak O, Gershkovich P, Lin M, Wasan EK, Zhao J, Owen D, Clement JG, Wasan KM. Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model: Lipids Health Dis. 2011 Aug 8;10:135.

Kagan L, Gershkovich P, Wasan KM, Mager DE. Physiologically Based Pharmacokinetic Model of Amphotericin B Disposition in Rats Following Administration of Deoxycholate Formulation (FungizoneR): Pooled Analysis of Published Data. AAPS J. 2011 Mar 23.

Fleischer JG, Rossignol D, Francis GA, Chan T, Lynn M, Wasan KM. Deactivation of the lipopolysaccharide antagonist eritoran (E5564) by high-density lipoprotein-associated apolipoproteins. Innate Immun. 2011 Mar 7.

Babovic S, Wasan KM. Impact of the trade-related aspects of intellectual property rights (TRIPS) agreement on India as a supplier of generic antiretrovirals. J Pharm Sci. 2011 Mar;100(3):816-21.

Twiddy AL, Leon CG, Wasan KM. Cholesterol as a potential target for castration-resistant prostate cancer. Pharm Res. 2011 Mar;28(3):423-37. Epub 2010 Aug 4.

Brown S, Babovic S, Wasan KM. Increasing access to essential medicines: diversifying Canada's approach. J Pharm Sci. 100(2):411-5. Pubmed.

Reid CS, Patrick DA, He S, Fotie J, Premalatha K, Tidwell RR, Wang MZ, Liu Q, Gershkovich P, Wasan KM, Wenzler T, Brun R, Werbovetz KA. Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation. Bioorg Med Chem. 19(1):513-23. Pubmed.

2010

Wasan EK, Gershkovich P, Zhao J, Zhu X, Werbovetz K, Tidwell RR, Clement JG, Thornton SJ, Wasan KM. A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model. PLoS Negl.Trop. Dis. 4(12): e913. Pubmed.

Al-Sarraf A, Al-Ghofaili K, Sullivan DR, Wasan KM, Hegele R, Frohlich J. Complete Apo AI deficiency in an Iraqi Mandaean family: case studies and review of the literature. J Clin Lipidol (2010) 4(5): 420-6. Pubmed.

Gershkovich P, Sivak O, Wasan EK, Magil AB, Owen D, Clement JG, Wasan KM. Biodistribution and tissue toxicity of amphotericin B in mice following multiple dose administration of a novel oral lipid-based formulation (iCo-009). J Antimicrob Chemother. (2010) 65(12): 2610-3. Pubmed

Babovic S, Wasan KM. Impact of the trade-related aspects of intellectual property rights (TRIPS) agreement on India as a supplier of generic antiretrovirals. J Pharm Sci. (2010) ePub ahead of print. Pubmed

Twiddy AL, Leon CG, Wasan KM. Cholesterol as a Potential Target for Castration-Resistant Prostate Cancer. Pharm Res. (2010) ePub ahead of print. Pubmed

Spiegel JM, Dharamsi S, Wasan KM, Yassi A, Singer B, Hotez PJ, Hanson C, Bundy DA. Which new approaches to tackling neglected tropical diseases show promise? PLoS Med. (2010) 7(5):e1000255 Pubmed

Gershkovich P, Sivak O, Sharma A, Barr AM, Procyshyn R, Wasan KM. Effect of hypertriglyceridemia on the pharmacokinetics and blood-brain barrier penetration of clozapine and norclozapine following administration to rats. Eur Neuropsychopharmacol. (2010) 20(8):545-52. PubMed

Gershkovich P, Wasan EK, Sivak O, Li R, Zhu X, Werbovetz KA, Tidwell RR, Clement JG, Thornton SJ, Wasan KM. Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice. J Antimicrob Chemother. (2010) 65(3):535-7 PubMed

Leon CG, Locke JA, Adomat HH, Etinger SL, Twiddy AL, Neumann RD, Nelson CC, Guns ES, Wasan KM. Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. Prostate (2010) 70(4):390-400 PubMed

Locke JA, Guns ES, Lehman ML, Ettinger S, Zoubeidi A, Lubik A, Margiotti K, Fazli L, Adomat H, Wasan KM, Gleave ME, Nelson CC. Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance. Prostate (2010) 70(3):239-51 PubMed

2009

Wasan KM, Wasan EK, Gershkovich P, Zhu X, Tidwell RR, Werbovetz KA, Clement JG, Thornton SJ. Highly Effective Oral Amphotericin B Formulation against Murine Visceral Leishmaniasis. J Infect Dis. 200(3): 357-60 (2009) PubMed

Wasan EK, Bartlett K, Gershkovich P, Sivak O, Banno B, Wong Z, Gagnon J, Gates B, Leon CG, Wasan KM. Development and characterization of oral lipid-based Amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans. Int J Pharm. 372(1-2):76-84 (2009). PubMed

Gershkovich P, Wasan EK, Lin M, Sivak O, Leon CG, Clement JG, Wasan KM. Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation. J Antimicrob Chemother. 64(1): 101-8 (2009). PubMed.

Gershkovich P, Darlington J, Sivak O, Constantinides PP, Wasan KM. Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds. J. Pharm. Sci. 98(7):2390-400 (2009). PubMed.

Tory R, Sachs-Barrable K, Goshko CB, Hill JS, Wasan KM. Tacrolimus-induced elevation in plasma triglyceride concentrations after administration to renal transplant patients is partially due to a decrease in lipoprotein lipase activity and plasma concentrations. Transplantation. 88(1): 62-8 (2009). Pubmed.

Thornton SJ, Wasan KM. The reformulation of amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis. Expert Opin Drug Deliv. 6(3):271-84 (2009). PubMed.

2008

Wasan KM, Thornton SJ, Bell I, Goulding RE, Gretes M, Gray AP, Hancock RE, Campbell B. The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world. J Pharm Sci. 98(3):791-4 (2008). PubMed.

Wasan KM, Brocks DR, Lee SD, Sachs-Barrable K, Thornton SJ. Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nat Rev Drug Discov. 7(1): 84-99 (2008). PubMed.

Wasan KM, Risovic V, Sivak O, Lee SD, Mason DX, Chiklis GR, McShane J, Lynn M, Wong N, Rossignol DP. Influence of plasma cholesterol and triglyceride concentrations and eritoran (E5564) micelle size on its plasma pharmacokinetics and ex vivo activity following single intravenous bolus dose into healthy female rabbits. Pharm Res. 25(1):176-82 (2008). PubMed.

Barta CA, Sachs-Barrable K, Feng F, Wasan KM. Effects of Monoglycerides on P-Glycoprotein: Modulation of the Activity and Expression in Caco-2 Cell Monolayers. Mol Pharm. 5(5): 863-75 (2008). PubMed.

Leon C, Jia J, Qiu G, Hill JS, Wasan KM. Modifications in low-density lipoprotein receptor expression affects Cyclosporin A cellular uptake and cytotoxicity.
J Pharm Sci. 97(6):2350-61 (2008). PubMed.

Locke JA, Wasan KM, Nelson CC, Guns ES, Leon CG. Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT). Prostate. 68(1):20-33 (2008). PubMed.

Porter CJ, Wasan KM, Constantinides P. Lipid-based systems for the enhanced delivery of poorly water soluble drugs. Adv Drug Deliv Rev. 60(6):615-6 (2008). PubMed.

Sachs-Barrable K, Lee SD, Wasan EK, Thornton SJ, Wasan KM. Enhancing drug absorption using lipids: a case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections. Adv Drug Deliv Rev. 60(6):692-701 (2008). PubMed.

Thornton SJ, Wong E, Lee SD, Wasan KM. Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism. Lipids Health Dis. 7:21 (2008). PubMed.

Tory, R, Sachs-Barrable K, Hill JS, Wasan KM. Cyclosporine A and Rapamycin induce in vitro cholesteryl ester transfer protein activity, and suppress lipoprotein lipase activity in human plasma. Int J Pharm. epub ahead of print (2008). PubMed.

*For a full list of Publications, visit the PubMed Website